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A revealing study demonstrated that a fusion construct of Mll exons 1–8 and lacZ, the gene encoding the non-oncogenic enzyme β-galactosidase, was able to cause leukemias in mice, …
WhatsApp: +86 18221755073The highly leukemogenic MLL fusion proteins have a unique mechanism of action. This review summarizes the current knowledge of how MLL fusions interact with the …
WhatsApp: +86 18221755073Enzomenib, CAS 241, DSP-5336, DSP5336, menin-MLL inhibitor, Enzomenib (DSP-5336) is a potent, and orally bioavailable menin-MLL interaction inhibitor with IC50 of 1.4 nM, …
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WhatsApp: +86 18221755073Rare MLL-ELL fusion transcripts in childhood acute myeloid … FISH analysis also demonstrated that MLL was split. RNA-sequencing showed that the translocation had generated an MLL-ELL …
WhatsApp: +86 18221755073Results: We generated DSP-5336, a novel, potent, and orally bioavailable MENIN-MLL interaction inhibitor for the treatment of acute leukemia patients with MLL -r or NPM1 …
WhatsApp: +86 18221755073These changes in chromatin suggest that the Menin-MLL interaction is critical for MLL or MLL fusion protein function and DOT1L occupancy at a restricted subset of genes that include well …
WhatsApp: +86 18221755073Based on the current guidelines and the current state of research, there are different diagnostic recommendations for patients with chronic myelomonocytic leukemia. We have summarized …
WhatsApp: +86 18221755073Menin is an essential co-factor of oncogenic MLL fusion proteins and the menin-MLL interaction is critical for development of acute leukemia in vivo. Targeting the menin-MLL interaction with …
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